HCG 2000 IU Injection

HCG 2000 IU Injection (Human Chorionic Gonadotropin) – Maintenance Dose for Hypogonadism, Luteal Phase Support and PCT

Reviewed by a licensed physician | Last updated: April 2026 Prescription advised | Always administered under medical supervision

What It Is

HCG 2000 IU Injection,  GENERIC Pregnyl / Novarel  contains Human Chorionic Gonadotropin (hCG) — a hormone that mimics luteinising hormone (LH) in the body. The 2000 IU vial is the maintenance and repeat-dose strength — distinct from the larger 5000 IU and 10000 IU trigger shot vials.

Why 2000 IU specifically exists as a separate strength:

The 2000 IU vial is purpose-built for protocols requiring smaller, frequent doses — where using a 5000 IU or 10000 IU vial per injection would mean discarding a significant proportion of each vial unused. For patients injecting 2–3 times per week over weeks or months, the 2000 IU vial is the most economical and practical option.

Available Indian brands at 2000 IU:

HCG 2000 IU vs 5000 IU vs 10000 IU — Which Dose for Which Use

The 2000 IU vial is the most cost-efficient choice for all repeat-dosing protocols.

What It Is Used For

Male Hypogonadism — Ongoing Testosterone Stimulation

The primary ongoing use. In men with hypogonadotropic hypogonadism — where the pituitary does not send adequate LH signals to the testes — hCG replaces the LH stimulus. HCG binds to LH receptors on testicular Leydig cells and directly drives testosterone production.

Standard protocol: 1000–2000 IU intramuscularly or subcutaneously, 2–3 times per week. This is a long-term ongoing regimen — patients inject regularly for months to years. The 2000 IU vial matches this dose exactly, eliminating waste from partially used larger vials.

Clinical advantages over testosterone replacement therapy (TRT):

• Preserves natural testicular size and function
• Maintains intratesticular testosterone (critical for spermatogenesis)
• Preserves fertility — TRT suppresses sperm production; hCG does not
• Often combined with TRT at lower doses to prevent testicular atrophy during testosterone treatment

IVF Luteal Phase Support

After egg retrieval in IVF, the corpus luteum needs support to produce progesterone for implantation. Some protocols use hCG 1500–2000 IU every 2–3 days for the first 1–2 weeks post-retrieval as luteal support — though progesterone pessaries/injections have largely replaced this approach in modern protocols due to OHSS risk. When hCG luteal support is prescribed, the 2000 IU vial matches the dose exactly.

Post-Cycle Therapy (PCT)

After anabolic steroid cycles, the hypothalamic-pituitary-testicular axis (HPTA) is suppressed. The testes have stopped producing testosterone and have partially atrophied. hCG restarts testicular function by providing the LH signal the pituitary is temporarily unable to send.

Standard PCT hCG protocol: 1000–2000 IU every 2–3 days for 2–3 weeks, followed by SERM therapy (clomiphene 50mg/day or tamoxifen 20mg/day for 4–6 weeks). The 2000 IU vial is the standard PCT vial choice — each vial provides exactly 1–2 injections at standard PCT doses.

Cryptorchidism in Boys

hCG stimulates testicular descent in boys with undescended testes, used before surgical intervention is considered. Dose: 500–1000 IU intramuscularly 3 times per week for 3–4 weeks. The 2000 IU vial provides 2–4 paediatric doses.

Dosage

Reconstitution: Add 1–2mL of supplied bacteriostatic water or water for injection to powder vial. Swirl gently. Use immediately or store reconstituted solution refrigerated at 2–8°C for up to 30 days if bacteriostatic water was used. Discard if using plain water for injection — use within 24 hours only.

Route: SC (subcutaneous — abdomen or thigh) or IM (intramuscular — upper outer thigh) as directed by your physician.

Side Effects

Men on ongoing protocols: Gynaecomastia (breast tissue growth) with prolonged use — particularly at higher doses. Fluid retention. Acne. Mood changes. Injection site reactions. Testicular pain at initiation (sign of stimulation — usually transient).

Women on luteal support: Mild OHSS symptoms possible — bloating, mild abdominal discomfort. Less risk than trigger shot doses but monitor. Breast tenderness.

Both: Headache. Fatigue. Injection site pain and bruising.

Serious — seek immediate attention: Severe abdominal pain, rapid weight gain, reduced urine output (severe OHSS in women). Severe allergic reaction — rash, swelling, difficulty breathing.

FAQ

Why choose 2000 IU over 5000 IU for hypogonadism treatment? If your prescribed dose is 1000–2000 IU per injection, using a 5000 IU vial means discarding 3000–4000 IU unused each time. The 2000 IU vial is sized to match maintenance doses exactly — significantly more economical for long-term treatment.

Can reconstituted HCG be stored for multiple doses? Only if reconstituted with bacteriostatic water for injection — then refrigerate at 2–8°C and use within 30 days. If reconstituted with plain water for injection, use within 24 hours and discard remaining solution.

Is HCG 2000 IU used as a fertility trigger shot? Generally not. The standard trigger shot doses are 5000 IU or 10000 IU. The 2000 IU vial is too small for triggering in most IVF protocols. It is occasionally used for luteal phase support after retrieval in 1500–2000 IU doses.

Can I combine HCG 2000 IU with testosterone replacement therapy? Yes — this is a common combination in men's health. HCG 500–1000 IU twice weekly alongside TRT maintains testicular function and intratesticular testosterone levels, preventing testicular atrophy and preserving fertility potential. Always under physician supervision.

Do you ship HCG 2000 IU internationally? Yes — cold-chain compliant discreet shipping to USA, UK, UAE.

References

1. Human Chorionic Gonadotropin — DrugBank DB00060 https://go.drugbank.com/drugs/DB00060
2. HCG in Male Hypogonadism and Fertility Preservation — PMC Review (2020) https://pmc.ncbi.nlm.nih.gov/articles/PMC7269709/
3. Luteal Phase Support in IVF — ESHRE Guideline on Ovarian Stimulation (2020) https://www.eshre.eu/Guidelines-and-Legal/Guidelines/Ovarian-Stimulation