Kaftrio (Trikafta) tablet

Product Details

Kaftrio Tablet (also known as Trikafta) contains a combination of Ivacaftor, Tezacaftor, and Elexacaftor. It is used for the treatment of cystic fibrosis (CF) in patients with at least one F508del mutation in the CFTR gene. Kaftrio helps improve lung function, reduce pulmonary exacerbations, and enhance overall quality of life in CF patients.

Uses:

• Cystic Fibrosis (CF): Approved for patients with at least one F508del mutation in the CFTR gene.
• Improves Lung Function: Helps in clearing mucus buildup in the lungs.
• Reduces Respiratory Infections: Lowers the frequency of pulmonary exacerbations.

How Kaftrio Works:

Kaftrio targets and improves CFTR protein function, helping regulate salt and water balance in the lungs and other organs, thus reducing mucus accumulation and improving breathing.

Common Side Effects:

• Headache
• Diarrhea
• Stomach pain
• Increased liver enzymes
• Skin rash

Serious Side Effects (Seek Medical Attention):

• Liver problems (yellowing of skin/eyes)
• Cataracts
• Breathing difficulties
• Severe rash or allergic reactions

Key Features:

✔ Combination therapy of Ivacaftor, Tezacaftor, and Elexacaftor
✔ Approved for F508del mutation CF patients
✔ Enhances lung function and respiratory health
✔ Reduces the risk of hospitalization due to CF complications

Precautions:

• Liver Function Monitoring: Regular LFT tests required.
• Avoid Grapefruit & Seville Oranges: May interfere with drug metabolism.
• Pregnancy & Breastfeeding: Consult a doctor before use.

FAQs:

1. What is Kaftrio used for?

   • It is used to treat cystic fibrosis in patients with at least one F508del mutation in the CFTR gene.

2. How does Kaftrio work?

   • It improves CFTR protein function, reducing mucus buildup in the lungs and making breathing easier.

3. Can I take Kaftrio with other medications?

   • Consult your doctor, as some medications may interact with Ivacaftor, Tezacaftor, and Elexacaftor.

4. Is Kaftrio safe for children?

   • Approved for use in children aged 6 years and older with an appropriate CF mutation.

5. Where can I buy Kaftrio tablets?

   • Available at specialty pharmacies or online through Milan Medicals.

References:

1. Cystic Fibrosis Foundation – https://en.wikipedia.org/wiki/Elexacaftor/tezacaftor/ivacaftor
2. European Medicines Agency (EMA) – https://www.ema.europa.eu/en/medicines/human/EPAR/kaftrio