Polivy 400 mg Injection

Product Details

Polivy 400 mg Injection contains Polatuzumab Vedotin, an antibody-drug conjugate (ADC) used in the treatment of diffuse large B-cell lymphoma (DLBCL). It works by targeting CD79b, a protein found on cancerous B-cells, delivering a chemotherapy agent directly to the tumor cells, leading to cell death while minimizing damage to normal cells.

Uses:

• Diffuse Large B-Cell Lymphoma (DLBCL) – Used in combination with other chemotherapy agents for treating relapsed or refractory cases.

How It Works:

Polatuzumab Vedotin binds to the CD79b protein on B-cell lymphoma cells, releasing a potent cytotoxic agent that disrupts cancer cell growth and survival.

Common Side Effects:

• Fatigue
• Nausea
• Low blood counts (neutropenia, anemia)
• Peripheral neuropathy
• Diarrhea

Precautions:

• Monitor blood counts regularly to prevent infections.
• Avoid in pregnancy due to potential harm to the fetus.
• Liver function tests should be conducted periodically.

Frequently Asked Questions (FAQ):

1. What is Polivy 400 mg Injection used for?
It is used for the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL).

2. How is Polivy administered?
Polivy is given as an intravenous (IV) infusion under the supervision of a healthcare professional.

3. Can Polivy be used as a first-line treatment?
It is mainly used for relapsed or refractory cases and not commonly for first-line therapy.

4. Does Polivy cause hair loss?
Hair loss is not a common side effect, but other chemotherapy-related side effects may occur.

5. Is Polivy available in India?
Yes, Polivy 400 mg Injection is available in India. You can buy it from Milan Medicals at competitive prices.

References:

1. Genentech. (2024). Polivy (Polatuzumab Vedotin) Prescribing Information. Retrieved from https://www.polivy.com/newly-diagnosed/rchp.html
2. European Medicines Agency (EMA). Polivy – Summary of Product Characteristics. Retrieved from https://reference.medscape.com/drug/polivy-polatuzumab-vedotin-1000337