Soliris 300mg Injection

Product Details

Soliris 300mg Injection contains eculizumab, a monoclonal antibody used to treat rare and life-threatening blood disorders, such as paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and generalized myasthenia gravis (gMG). Eculizumab works by inhibiting the complement system, a part of the immune system that may be overactive in these conditions, helping to reduce inflammation and prevent destruction of red blood cells.

Uses:

1. Paroxysmal Nocturnal Hemoglobinuria (PNH): Helps reduce the destruction of red blood cells and associated complications.
2. Atypical Hemolytic Uremic Syndrome (aHUS): Controls overactivation of the immune system to prevent blood clots, kidney damage, and other complications.
3. Generalized Myasthenia Gravis (gMG): Used for patients who are anti-acetylcholine receptor antibody-positive, to reduce symptoms and improve daily functioning.

How Soliris 300 mg Injection Works:

Eculizumab binds to a protein called C5, which is part of the complement system. By preventing C5 from being cleaved, it blocks the activation of the terminal complement cascade, thereby reducing inflammation and preventing damage to cells.

Common Side Effects:

• Headache
• Upper respiratory infections
• Back pain
• Nausea
• Fatigue

Serious Side Effects (Seek Immediate Medical Attention):

• Increased risk of infections, especially meningococcal infections.
• Severe allergic reactions such as difficulty breathing, swelling, or rash.

Key Features:

• Contains eculizumab, a complement inhibitor monoclonal antibody.
• Effective for managing rare blood disorders and autoimmune conditions.
• Administered via intravenous infusion under medical supervision.
• Reduces disease progression and improves quality of life in treated conditions.

Precautions:

• Meningococcal Vaccination: Patients should receive vaccination against meningococcal infections before treatment due to increased infection risk.
• Regular Monitoring: Healthcare providers may conduct frequent blood tests to monitor progress and detect any side effects.

Frequently Asked Questions (FAQ):

1. What conditions does Soliris treat?
   It is used for treating PNH, aHUS, and generalized myasthenia gravis, among other rare disorders.
2. How is Soliris administered?
   It is given as an intravenous infusion under the supervision of a healthcare provider, typically at a medical facility.
3. Why is meningococcal vaccination important before using Soliris?
   Eculizumab increases the risk of severe meningococcal infections, so vaccination helps reduce this risk.
4. Are there any dietary restrictions while using Soliris?
   Generally, no specific dietary restrictions exist, but discuss any supplements or dietary concerns with a healthcare provider.

References:

1. Alexion Pharmaceuticals – Soliris Product Information
   Available from: https://www.medicines.org.uk/emc/product/362/smpc
2. National Institute for Health and Care Excellence (NICE) – Eculizumab Overview
   Available from: https://go.drugbank.com/drugs/DB01257