Andractim Gel (Dihydrotestosterone 2.5%)

Andractim Gel is a prescription-only topical hormone therapy containing 2.5% dihydrotestosterone (DHT), manufactured by Besins Healthcare. It is prescribed by physicians for gynecomastia management, male hypogonadism, and select androgen deficiency conditions. DHT cannot convert to estrogen, which is why clinicians select it specifically when an estrogen-sparing androgen is needed.

Regulatory Status

Andractim is not FDA-approved for marketing in the United States and is not available through standard U.S. retail pharmacies. It is approved and prescribed in parts of Europe and other markets. Any international order requires a valid prescription and is subject to each destination country’s import regulations for prescription hormonal medication. Buyers are responsible for confirming their own country’s import rules before ordering.

What Andractim Gel Is Used For

• Gynecomastia management: DHT raises the androgen-to-estrogen ratio locally, which is the mechanism behind its use in reducing glandular breast tissue in men.
• Male hypogonadism: used in specific cases where androgen replacement is indicated and an estrogen-sparing option is clinically preferred.
• Microphallus treatment: historically used under specialist pediatric endocrinology supervision; this use requires direct physician management and is not a self-directed treatment.

How Andractim Gel Works

Andractim delivers DHT directly through the skin into the bloodstream, bypassing the liver and avoiding conversion to estrogen. Unlike testosterone, DHT cannot be converted by the aromatase enzyme into estrogen. This is the core pharmacological reason it’s selected over standard testosterone gel for estrogen-sensitive conditions like gynecomastia.

Dosage and Application

A typical prescribed dose is 2.5g to 5g of gel applied once daily to clean, dry skin, exactly as directed by the prescribing physician. Do not adjust dosage without medical guidance.

• Apply using the supplied dosing spatula to the area specified by your physician (commonly chest or abdomen)
• Allow 5 minutes to dry before dressing
• Avoid washing the application site for at least 6 hours
• Wash hands thoroughly after every application to prevent transfer to others

Safety, Precautions and Contraindications

Andractim is contraindicated in women, in men with a history of prostate or breast cancer, and requires regular prostate (PSA) monitoring during use.

• Prostate monitoring: regular PSA testing is recommended for men on DHT therapy
• Skin irritation: mild redness at the application site can occur and typically resolves
• Transfer risk: accidental skin-to-skin contact can transfer DHT to women or children — wash hands and cover the area after application
• Not for use by women or anyone with a personal history of prostate or breast cancer

Andractim vs. Standard Testosterone Gel

The key difference is aromatization: testosterone gel can convert to estrogen in the body, while Andractim’s DHT cannot. This makes Andractim the clinically preferred choice when a physician specifically wants to raise androgen activity without any corresponding rise in estrogen — most notably in gynecomastia, where excess estrogenic activity is part of the underlying problem.

Frequently Asked Questions

Is Andractim Gel Amazon sale legal to import?

Andractim requires a valid prescription, and import legality depends on the destination country’s individual rules for prescription hormonal medications. Some countries permit personal-use imports of prescribed medication with documentation; others restrict it. Check your country’s customs and pharmaceutical import regulations, or ask your prescribing physician, before ordering.

How long does one tube of Andractim last?

An 80g tube typically lasts 16 to 30 days at a standard prescribed dose of 2.5g–5g per day. Actual duration depends on your physician’s specific dosing instructions.

What’s the difference between Andractim and regular testosterone gel?

Andractim is pure DHT and cannot convert to estrogen, while testosterone gel can. This is why physicians prescribe Andractim specifically for estrogen-sensitive conditions like gynecomastia, where standard testosterone therapy could worsen symptoms.

Can women use Andractim Gel?

No. Andractim is contraindicated for use by women. Even incidental skin contact with a treated area should be avoided, which is why hand-washing after application is part of the standard safety protocol.

Does Andractim require a prescription?

Yes. Andractim is a prescription-only medication in every market where it is legally available, and should only be used under physician supervision with regular monitoring.

References

1. Great Ormond Street Hospital — Dihydrotestosterone (Andractim 2.5% Gel) Patient Information
2. Wikipedia — Androstanolone (DHT) Clinical Data

Medically reviewed. Last updated: [19/06/2026]. This content is for informational purposes and does not replace consultation with a licensed physician.