Apomorphine 3 mg Tablet

Apomorphine 3mg Sublingual Tablet – Generic Uprima | Dopamine-Pathway ED Treatment

Reviewed by a licensed physician | Last updated: April 2026 Prescription advised | Not FDA-approved for ED in the USA

What It Is

Apomorphine 3mg Sublingual Tablet contains Apomorphine Hydrochloride — a dopamine agonist and the active molecule in Uprima®, which was approved in Europe specifically for erectile dysfunction before market withdrawal. The Indian generic formulation (including Apotab and similar brands) makes this molecule available globally through export.

This is a fundamentally different type of ED treatment from Viagra, Cialis, and Levitra. Those drugs (PDE5 inhibitors) work in the penis — relaxing blood vessels to increase blood flow. Apomorphine works in the brain — activating dopamine receptors in the hypothalamus that trigger the natural erection reflex through the nervous system.

Why Men Seek Apomorphine Specifically

The majority of men seeking apomorphine 3mg sublingual tablets fall into one of three groups:

Men on nitrate medications — PDE5 inhibitors (Viagra, Cialis, Levitra) are absolutely contraindicated with nitrates (prescribed for angina and heart conditions). The combination causes dangerous blood pressure drops. Apomorphine works through an entirely different pathway and does not interact with nitrates — making it the only oral ED option worth researching for this group.

Men with psychological or neurogenic ED — Apomorphine works centrally through the brain's arousal pathway. Clinical evidence shows it is particularly effective when ED has a psychological or neurogenic component rather than purely vascular causes.

Men who did not respond to PDE5 inhibitors — In a study of over 5,000 ED patients, sublingual apomorphine at 2–3mg produced meaningful erections in a clinically significant proportion of men who had not achieved results with other approaches.

How It Works

Place one tablet under the tongue 15–20 minutes before sexual activity. It dissolves rapidly and absorbs through the sublingual mucosa directly into the bloodstream — bypassing first-pass liver metabolism for fast, predictable onset.

Apomorphine binds to D1 and D2 dopamine receptors in the hypothalamus and midbrain. This activates the brain's natural erection initiation pathway — sending excitatory signals down the spinal cord to the sacral parasympathetic nerves, which cause penile smooth muscle relaxation and arterial dilation. Sexual stimulation is still required for the erection to occur.

Onset: Detectable in plasma within 10 minutes. Erection typically within 18–20 minutes.

Dosage

Start at 2mg. If response is inadequate after several attempts, increase to 3mg. Do not exceed one tablet per 8-hour period. Do not swallow — place under tongue and allow to dissolve completely.

Who Should Not Use It

Do not use if: you take nitrates or nicorandil — but note this is the opposite of PDE5 inhibitors; apomorphine itself does not interact with nitrates — however the combination still requires physician review as both affect cardiovascular function. Do not use if you have significant hypotension, severe hepatic impairment, severe heart failure, or known hypersensitivity to apomorphine. Not for use with alcohol. Caution in elderly patients — higher syncope risk.

Do not drive or operate machinery for at least 2 hours after taking — dizziness and syncope risk.

Side Effects

Common (approximately 7%): Nausea and headache — both typically mild and transient. Dizziness. Yawning.

Uncommon but serious: Syncope (fainting) — occurs in a small percentage of patients, most often on the first dose. Sit or lie down after taking for the first few times. Hypotension (low blood pressure).

Management: Take with food if nausea is significant. Avoid alcohol entirely. Rise slowly from sitting or lying positions.

Important Regulatory Note by Country

FAQ

Is apomorphine the same as Uprima? Yes — Uprima contained apomorphine HCl at 2mg and 3mg sublingual doses for ED. Generic tablets contain the identical molecule at the same strengths.

Can I take apomorphine if I'm on heart medication (nitrates)? Unlike Viagra and Cialis, apomorphine does not have a direct nitrate interaction — but you must consult your cardiologist before use as apomorphine itself can lower blood pressure. It is worth discussing specifically as an alternative for men on nitrates who need ED treatment.

How is this different from Viagra? Viagra increases blood flow to the penis. Apomorphine activates the brain's dopamine pathway to initiate the erection reflex. They work on entirely different systems — apomorphine is the only brain-pathway oral ED tablet available.

Will it work for me? Clinical data in 5,000+ patients shows best results in psychological and neurogenic ED. Results are more modest in severe vascular ED. If Viagra and Cialis have not worked due to vascular reasons, apomorphine may offer similar limitations — discuss with your doctor.

References

1. Uprima (Apomorphine HCl) — European Assessment Report, EMEA (Approved 2001) https://registrasiobat.pom.go.id/files/assesment-reports/obat_baru/Uprima.pdf
2. Apomorphine — Drugs.com Drug Information (Updated February 2025) https://www.drugs.com/apomorphine.html
3. Apomorphine for ED — Ro Health (December 2025). 5,000-patient study; 2–3mg dose range. https://ro.co/erectile-dysfunction/apomorphine-for-ed/
4. Does Apomorphine Work for ED — Rex MD (October 2025) https://rexmd.com/learn/apomorphine-for-erectile-dysfunction
5. Apomorphine for ED — Hims (August 2025). Uprima history; dopamine mechanism. https://www.hims.com/blog/apomorphine-for-ed