Crinone 8% Vaginal Gel is a prescription vaginal progesterone medicine containing 90mg of progesterone per 1.125g dose. It is a bioadhesive vaginal gel supplied in single-use applicators and is used for progesterone support in specified infertility and assisted-reproductive-treatment settings.
Crinone 8% is a branded progesterone vaginal gel, not a progesterone tablet, pessary or topical skin cream. Its formulation uses a polycarbophil delivery system designed to adhere to the vaginal mucosa and provide prolonged progesterone release.
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In UK labeling, Crinone 8% is indicated for infertility due to inadequate luteal phase and for specified IVF treatment where progesterone support is required.
The U.S. labeling also identifies Crinone 8% for progesterone supplementation or replacement as part of assisted reproductive technology treatment in women with progesterone deficiency, with additional U.S. labeling for secondary amenorrhea.
Indications can vary between countries, so the approved local product information should always be followed.
Progesterone is a naturally occurring steroid hormone involved in preparing and maintaining the endometrium during the reproductive cycle and early pregnancy.
After vaginal administration, Crinone delivers progesterone locally through its bioadhesive gel system. The UK SmPC describes the polycarbophil-based formulation as attaching to the vaginal mucosa and providing prolonged release of progesterone.
Crinone 8% is specifically associated with progesterone support during assisted reproductive technology (ART).
Progesterone plays an important role in preparing the endometrium for implantation and supporting the hormonal environment required during early pregnancy. U.S. labeling identifies Crinone 8% as part of an ART treatment program for women requiring progesterone supplementation or replacement.
Crinone should therefore be distinguished from general-purpose vaginal moisturising gels and non-hormonal fertility products.
Crinone 8% is a vaginal progesterone gel.
Other progesterone medicines may be supplied as:
These dosage forms are not automatically interchangeable. A progesterone medicine with the same active ingredient may have a different route, concentration, absorption profile, formulation and approved indication.
Crinone 8% should not be confused with over-the-counter or cosmetic progesterone creams.
Crinone is a regulated medicinal vaginal gel containing a specified concentration of progesterone and supplied in single-use applicators. It is formulated specifically for vaginal administration and should be used according to its prescription and local product information.
The product is supplied in a specially designed single-use applicator. UK labeling states that each applicator contains 1.45g of gel and delivers 1.125g of gel containing 90mg progesterone. The applicators are individually wrapped and supplied in packs of 6 or 15 in UK labeling.
U.S. labeling identifies the 8% presentation as a single-use prefilled applicator delivering 90mg progesterone in 1.125g of gel.
Crinone is a prescription hormonal medicine and is not appropriate for everyone.
The prescribing information should be reviewed for contraindications, interactions, abnormal vaginal bleeding, thromboembolic risk factors, liver-related conditions, hormone-sensitive cancers and other relevant medical considerations.
Patients should inform their healthcare professional about current medicines, previous hormone-related conditions and any history of blood clots or significant liver disease before treatment.
Seek medical attention for serious or unexpected symptoms, particularly symptoms suggestive of a blood clot, severe allergic reaction or significant abnormal bleeding.
Potential adverse effects can vary between patients and may include local vaginal irritation or discomfort, discharge, breast tenderness, headache, bloating, fatigue, mood changes and other progesterone-related effects.
The presence or severity of side effects may depend on individual sensitivity, treatment duration and the underlying fertility-treatment protocol.
Customers searching for Crinone 8% Vaginal Gel UK, Crinone 8% Progesterone Gel, Crinone 90mg Vaginal Gel, Buy Crinone 8% Online, Crinone Gel UK, Crinone 8 Gel Price, Crinone 8% IVF Gel, Crinone Progesterone Gel USA and Crinone 8% Gel Australia should verify the exact country-specific product, pack size and prescription requirements.
Crinone 8% is listed in the UK medicines database as a prescription-only medicine, while current U.S. DailyMed labeling also identifies Crinone as an Rx-only prescription drug.
Crinone 8% is registered in multiple markets. Australia’s TGA database lists CRINONE 8% progesterone 90mg/1.125g gel tube as an ARTG medicine sponsored by Merck Healthcare Pty Ltd.
Country-specific formulations, sponsors, pack sizes and authorized indications can differ, so international listings should not be assumed to be identical.
What is Crinone 8% Vaginal Gel?
Crinone 8% is a prescription vaginal progesterone gel containing 90mg progesterone in each delivered 1.125g dose.
What is Crinone 8% used for?
It is used for progesterone support in specified infertility and assisted-reproductive-treatment settings. The exact approved indications vary by country.
How much progesterone is in Crinone 8%?
Each delivered 1.125g dose contains 90mg of progesterone.
Is Crinone 8% a vaginal gel or cream?
It is a vaginal gel, not a topical progesterone cream.
Is Crinone the same as generic progesterone?
Crinone is a branded product containing progesterone. Generic progesterone products may use different formulations, dosage forms, strengths and manufacturers.
Is Crinone 8% used during IVF?
Yes. Crinone 8% is used for progesterone supplementation in specified IVF/ART treatment protocols.
Is Crinone 8% available in the USA?
Current U.S. DailyMed labeling lists Crinone progesterone gel as an Rx-only human prescription drug and includes an 8% presentation containing 90mg progesterone per 1.125g delivered dose.
Is Crinone 8% available in Australia?
The Australian TGA ARTG database lists Crinone 8% progesterone 90mg/1.125g gel tube as a registered medicine.
What is the difference between Crinone 4% and Crinone 8%?
The concentration differs: Crinone 4% contains 45mg progesterone per 1.125g delivered dose, while Crinone 8% contains 90mg.
Is Crinone 8% prescription only?
Yes. It is identified as a prescription-only medicine in UK and U.S. labeling.
Last Updated: September 22, 2026
Medical Disclaimer: This information is provided for educational and product-information purposes only and is not a substitute for professional medical advice, diagnosis or treatment. Crinone 8% is a prescription hormonal medicine. Always follow the current product information supplied in your country and consult a qualified healthcare professional before starting, stopping or changing treatment.
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