Levosimendan Injection

Levosimendan Injection generic for Simadax  is unique because it is a calcium sensitizer. Most heart-strengthening drugs (like dobutamine) increase the amount of calcium inside heart cells, which can cause dangerous arrhythmias and increase oxygen consumption. Levosimendan, however, simply makes the existing calcium “work harder” by stabilizing the protein (Troponin C) responsible for muscle contraction.

Why Levosimendan is the Clinical Gold Standard

• Dual-Action Support: Simultaneously increases cardiac output (pumping force) and decreases afterload (resistance in blood vessels).

• No “Oxygen Debt”: Improves heart performance without forcing the heart to consume more oxygen, which is vital for failing hearts.

• Extended Effects: Thanks to its active metabolite (OR1896), the benefits of a single infusion can last for 7 to 10 days.

• Beta-Blocker Compatible: Unlike many other inotropes, Levosimendan’s effect is not blocked by beta-blocker medications commonly taken by heart patients.

Clinical Administration & Storage Guidelines

1. Strictly In-Hospital: This medication is administered as a continuous intravenous infusion over 24 hours.

2. Dosage: Usually starts with a loading dose followed by a maintenance infusion (0.05 to 0.2 µg/kg/min).

3. Mandatory Cold-Chain: Must be stored in a refrigerator (2°C to 8°C). The solution is naturally yellow/orange; this is normal and does not indicate loss of potency.

4. Monitoring: Continuous monitoring of ECG, blood pressure, and potassium levels is required during and for several days after the infusion.

Frequently Asked Questions (FAQs)

1. What is the main use of Levosimendan 12.5mg? It is used for the short-term treatment of severe, acutely decompensated heart failure when standard diuretics and vasodilators are not enough to stabilize the patient.

2. Is Levosimendan better than Dobutamine? Clinical studies (like the LIDO trial) have shown that Levosimendan often provides better hemodynamic improvement and has a lower risk of mortality compared to dobutamine in certain heart failure settings.

3. Does Milan Medicals ship Levosimendan to the USA and UAE? Yes. Levosimendan is highly temperature-sensitive. we provide validated cold-chain shipping with temperature tracking to ensure the medication remains between 2°C and 8°C during transit to the USA, UAE, KSA, and UK.

4. Can Levosimendan cause low blood pressure? Yes, hypotension (low blood pressure) is a common side effect due to its vasodilatory properties. This is why it must be administered in a hospital where blood pressure can be monitored constantly.

5. What are the storage requirements? The vials must be kept refrigerated. Once diluted for infusion, the solution should ideally be used immediately, though it remains stable for up to 24 hours if kept cool.

References:

🔗 https://go.drugbank.com/drugs/DB00922
🔗 https://janesthanalgcritcare.biomedcentral.com/articles/10.1186/s44158-021-00030-7