Sybrava Injection contains Inclisiran 284 mg, a small interfering RNA (siRNA) that targets and reduces LDL cholesterol levels.

Uses:

✔ Primary Hypercholesterolemia (including familial hypercholesterolemia)
✔ Mixed Dyslipidemia
✔ Atherosclerotic Cardiovascular Disease (ASCVD) – for patients needing additional LDL-C lowering despite statin use

How Sybrava Works:

Inclisiran is a first-in-class siRNA that inhibits the production of PCSK9 protein in the liver. By reducing PCSK9, it enhances LDL receptor recycling and significantly lowers LDL cholesterol levels over time.

Dosage & Administration:

• Initial Dose: 284 mg subcutaneous injection at Day 0

• Second Dose: At 3 months

• Maintenance: Every 6 months thereafter

• Administered by a healthcare professional

• Can be used alongside statins or as monotherapy in statin-intolerant patients

Common Side Effects:

Injection site reactions (redness, pain, swelling)
Muscle pain
Arthralgia
Headache
Fatigue

Serious Side Effects (Seek Medical Help):

Hypersensitivity reactions
Liver enzyme elevations
Allergic angioedema (rare)

Precautions & Drug Interactions:

⚡ Pregnancy & Breastfeeding: Use only if prescribed; not enough human data available
⚡ Liver Function: Caution in patients with liver impairment
⚡ Kidney Impairment: Dose adjustment not required, but monitor in severe cases
⚡ Drug Interactions: No major interactions, but report all ongoing medications to your doctor

FAQs – Frequently Asked Questions

What is Sybrava used for?
Sybrava is used to lower LDL-C in patients with high cholesterol or ASCVD who require additional LDL-lowering beyond diet and statins.

Is Sybrava a statin?
No, Sybrava (Inclisiran) is not a statin. It works through RNA interference and complements statin therapy.

How is Sybrava administered?
It is given as a subcutaneous injection by a healthcare provider initially, then every 6 months.

Can I take Sybrava if I’m allergic to statins?
Yes, it is suitable for patients with statin intolerance, but always consult your cardiologist.

Where can I buy Sybrava 284 mg Injection online?
You can order authentic Inclisiran (Sybrava) from Milan Medicals with global shipping.