Tenectelex 40 mg Injection

Tenectelex 40 mg Injection contains tenecteplase, a recombinant tissue plasminogen activator (rtPA) used as a thrombolytic agent to dissolve blood clots. It is primarily indicated for the treatment of acute myocardial infarction (heart attack) to restore blood flow to the heart muscle. Tenecteplase works by breaking down fibrin, a protein that forms clots, thereby facilitating the body’s natural clot-dissolving process.

Uses:

1. Acute Myocardial Infarction (AMI): Administered to dissolve clots in the coronary arteries and improve blood flow to the heart muscle during a heart attack.
2. Thrombolytic Therapy: Used in specific cases where rapid clot dissolution is necessary to prevent tissue damage or organ failure.

How Tenectelex Works: Tenecteplase acts by binding to fibrin in blood clots, converting plasminogen to plasmin, which breaks down the fibrin mesh and effectively dissolves clots. This helps restore normal blood flow and prevents further damage to heart tissue.

Common Side Effects:

• Bleeding at the injection site
• Nausea or vomiting
• Hypotension (low blood pressure)
• Mild allergic reactions (rash or itching)

Serious Side Effects (Seek Immediate Medical Attention):

• Severe or prolonged bleeding (internal or external)
• Cerebral hemorrhage (rare but serious)
• Hematoma (localized bleeding)

Key Features:

• Contains tenecteplase, a highly fibrin-specific thrombolytic agent.
• Rapidly dissolves blood clots during acute myocardial infarction.
• Administered intravenously under medical supervision.
• Reduces the risk of heart muscle damage and complications related to heart attacks.

Precautions:

• Pregnancy Safety: The safety of Tenectelex during pregnancy is not fully established. Use with caution and only if clearly needed.
• Bleeding Risks: Careful monitoring for any signs of bleeding is crucial during and after administration.

Frequently Asked Questions (FAQ):

1. What is Tenectelex 40 mg Injection used for?
   Tenectelex is used to dissolve blood clots in patients experiencing acute myocardial infarction (heart attack), improving blood flow and preventing heart damage.
2. How is Tenectelex administered?
   It is administered as a single intravenous injection by a healthcare professional in an emergency setting.
3. Can Tenectelex cause bleeding?
   Yes, bleeding is a possible side effect. Patients will be closely monitored for any signs of excessive or prolonged bleeding during and after treatment.

References:

1. Tenecteplase Drug Information – Thrombolytic Therapy
   Available from: https://www.ncbi.nlm.nih.gov/books/NBK592420/
2. Clinical Guidelines for Myocardial Infarction Treatment
   Available from: https://go.drugbank.com/drugs/DB00031