Yohimbine Hydrochloride 5mg Tablets

Alpha-2 Adrenergic Receptor Antagonist

Last Updated: June 27, 2026
Medical Review Status: Reviewed for scientific accuracy
Reviewed By: Pharmaceutical Affairs Team
Reading Time: 6 min read

Quick Facts

Quick Answer

Yohimbine Hydrochloride 5 mg is an alpha-2 adrenergic receptor antagonist that increases sympathetic nervous system activity by blocking presynaptic alpha-2 receptors. It has historically been prescribed in certain countries for selected cases of erectile dysfunction and has also been investigated in clinical research involving sexual health, vascular function, metabolism, and autonomic nervous system regulation. Regulatory approval and clinical use vary between countries.

Why is Yohimbine Different?

• Selective alpha-2 adrenergic receptor antagonist
• Orally administered tablet formulation
• Acts through central and peripheral adrenergic pathways
• Historically studied for erectile dysfunction and vascular function
• Investigated in metabolic and autonomic nervous system research
• Regulatory status differs across international markets

Product Overview

Yohimbine Hydrochloride 5 mg Tablets contain a purified pharmaceutical form of yohimbine, an indole alkaloid originally isolated from the bark of the Pausinystalia yohimbe tree. Unlike herbal yohimbe supplements, pharmaceutical-grade Yohimbine Hydrochloride contains a standardized active ingredient and has been investigated in controlled clinical settings.

Yohimbine works by selectively blocking presynaptic alpha-2 adrenergic receptors, resulting in increased norepinephrine release and enhanced sympathetic nervous system activity. This pharmacological action has led to investigations involving erectile dysfunction, vascular physiology, autonomic nervous system disorders, body composition, and exercise metabolism.

Although Yohimbine has been prescribed in some countries for selected clinical indications, its regulatory approval differs worldwide. In the United States, prescription Yohimbine Hydrochloride is distinct from over-the-counter yohimbe dietary supplements, which are not standardized pharmaceutical products. Healthcare professionals should consult local prescribing information before recommending its use.

This page provides scientific and educational information regarding Yohimbine Hydrochloride and should not be interpreted as medical advice or a recommendation for treatment.

Product Information

Mechanism of Action

Yohimbine competitively blocks presynaptic alpha-2 adrenergic receptors, increasing norepinephrine release and sympathetic nervous system activity. These effects may influence vascular tone, blood flow, neurotransmission, and physiological responses mediated by adrenergic signaling.

Clinical Research Areas

• Erectile Dysfunction
• Male Sexual Health
• Autonomic Nervous System Disorders
• Orthostatic Hypotension Research
• Vascular Function
• Exercise Physiology
• Body Composition Research
• Metabolic Studies

Potential Pharmacological Effects

• Increased sympathetic nervous system activity
• Enhanced norepinephrine release
• Modulation of vascular function
• Central nervous system stimulation
• Adrenergic receptor blockade

Safety Information

Yohimbine may cause increased heart rate, elevated blood pressure, anxiety, restlessness, tremor, dizziness, insomnia, headache, nausea, and gastrointestinal discomfort. Individuals with cardiovascular disease, uncontrolled hypertension, psychiatric disorders, kidney disease, or liver impairment should consult a qualified healthcare professional before use where legally available.

Drug Interactions

Yohimbine may interact with antidepressants, antihypertensive medications, stimulant drugs, monoamine oxidase inhibitors (MAOIs), central nervous system stimulants, and medications affecting blood pressure or heart rhythm. Medical supervision is recommended.

Storage

Store below 25°C in a dry place, protected from moisture and direct sunlight. Keep out of reach of children.

Frequently Asked Questions

What is Yohimbine Hydrochloride?

Yohimbine Hydrochloride is a pharmaceutical alpha-2 adrenergic receptor antagonist historically used in selected countries for certain medical indications and investigated in several areas of clinical research.

Is Yohimbine approved worldwide?

No. Regulatory approval and availability vary considerably between countries. Healthcare professionals should consult local prescribing regulations.

Is Yohimbine the same as yohimbe supplements?

No. Pharmaceutical Yohimbine Hydrochloride contains a standardized active ingredient, whereas herbal yohimbe supplements may contain variable concentrations and are not equivalent prescription medicines.

What does Yohimbine do?

Yohimbine blocks alpha-2 adrenergic receptors, increasing norepinephrine release and sympathetic nervous system activity.

References

1. FDA Drug Information.
2. National Institutes of Health (NIH).
3. European Medicines Agency publications.
4. Clinical pharmacology literature.
5. Peer-reviewed studies on Yohimbine Hydrochloride.

Medical Disclaimer

This information is provided for educational purposes only. Yohimbine Hydrochloride has varying regulatory approval worldwide and may not be approved for medical use in all countries. This content should not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional regarding appropriate medical care and local prescribing regulations.