Phenergan Injection 25 mg/mL (Promethazine Hydrochloride)

Phenergan Injection 25 mg/mL is a prescription medicine containing promethazine hydrochloride, a first-generation antihistamine with additional sedative and antiemetic properties.

It is used for selected allergic conditions and other clinical indications specified in the applicable product information. Depending on the authorized formulation and jurisdiction, uses may include symptomatic treatment of allergic conditions, sedation and selected perioperative applications.

Phenergan injection is intended for administration by qualified healthcare professionals. Its sedative effects, respiratory risks and potential to cause severe injection-site tissue injury make appropriate patient assessment and administration essential.

Product Information

• Product Name: Phenergan Injection
• Active Ingredient: Promethazine hydrochloride
• Strength: 25 mg/mL
• Dosage Form: Sterile solution for injection
• Drug Class: First-generation H1 antihistamine
• Therapeutic Category: Antiallergic and sedating medicine
• Route of Administration: Primarily deep intramuscular injection, according to the applicable product label
• Common Pack Presentation: 1 mL or 2 mL ampoules
• Manufacturer/Marketing Authorization Holder: Verify current packaging
• Prescription Requirement: Subject to local regulations

Uses and Clinical Applications

Phenergan Injection may be used in selected clinical settings, depending on the approved product information.

• Allergic Conditions: Symptomatic relief of certain allergic conditions affecting the skin and upper respiratory tract.
• Urticaria and Allergic Symptoms: May be used for selected allergic reactions under medical supervision.
• Sedation: May be used for specified sedative indications when clinically appropriate.
• Perioperative Care: May be used as an adjunct in selected preoperative settings.
• Nausea and Vomiting: Certain promethazine injection product labels include specified antiemetic indications.

Approved uses differ by country and formulation. Phenergan is not a substitute for epinephrine in the emergency treatment of anaphylaxis.

Dosage and Administration

Phenergan Injection must be administered by a qualified healthcare professional according to the prescribed regimen and the exact product instructions.

Deep intramuscular injection is the preferred route in the referenced product information. Intravenous administration carries particular risk and must follow the applicable product-specific restrictions, dilution requirements and monitoring procedures.

Subcutaneous and intra-arterial administration must not be used. Incorrect administration or leakage into surrounding tissue can cause severe tissue damage, including necrosis and gangrene.

Do not self-administer this medicine or use dosing instructions intended for another promethazine formulation.

Possible Side Effects

Possible adverse effects include:

• Drowsiness or sedation
• Dizziness and impaired coordination
• Dry mouth
• Blurred vision
• Constipation
• Low blood pressure
• Injection-site pain or irritation

Serious reactions may include respiratory depression, severe allergic reactions, cardiovascular effects and tissue injury associated with improper injection.

Seek urgent medical assistance for difficulty breathing, collapse, severe confusion or signs of a serious injection-site complication.

Warnings and Precautions

Before administration, the healthcare professional should review the patient’s medical history, current medicines and risk factors.

Important precautions include:

• Severe tissue injury: Incorrect administration can cause chemical irritation, tissue necrosis and gangrene.
• Respiratory depression: Promethazine can suppress breathing, particularly when combined with opioids, sedatives or other central nervous system depressants.
• Children: Injectable promethazine is contraindicated in children younger than 2 years because of the risk of potentially fatal respiratory depression. Additional age-specific restrictions apply according to the product label.
• Sedation: Patients may experience significant drowsiness and impaired alertness.
• Other medicines: Inform the healthcare professional about all medicines being taken, especially opioids, sedatives and drugs that cause drowsiness.
• Sulphite sensitivity: Certain formulations contain sulphites, which may cause reactions in susceptible individuals.
• Anaphylaxis: Phenergan is not a replacement for epinephrine, the first-line emergency medicine for anaphylaxis.

Follow the official product information for complete contraindications, warnings and precautions.

Storage Instructions

Store Phenergan Injection in its original carton to protect it from light, following the manufacturer’s instructions. Keep ampoules secure and out of the reach of children.

Inspect the solution before administration. Do not use discoloured solutions, damaged ampoules or expired products.

Ordering and Availability

For Phenergan Injection 25 mg/mL pricing, ampoule sizes and availability, contact the supplier to confirm the exact product, manufacturer, pack quantity and current stock.

Registration, prescription requirements, approved indications and import eligibility vary by country. Confirm local requirements and obtain the medicine through an authorized pharmacy or eligible supplier.

Frequently Asked Questions

1. What is Phenergan Injection used for?

It contains promethazine hydrochloride, a sedating antihistamine used for selected allergic conditions and other indications specified in the approved product information.

2. What is the strength of Phenergan Injection?

The formulation covered here contains 25 mg of promethazine hydrochloride per mL. Confirm the concentration printed on the ampoule.

3. What is the generic name of Phenergan Injection?

The active ingredient is promethazine hydrochloride.

4. What is the price of Phenergan Injection?

Price depends on the ampoule volume, pack size, supplier and destination market. Request a quotation for the exact product.

5. Can Phenergan Injection be administered intravenously?

The preferred route in the referenced product information is deep intramuscular injection. Intravenous use carries serious tissue-injury risks and is subject to strict product-specific restrictions. It must not be attempted outside appropriate clinical supervision.

6. Is Phenergan Injection suitable for children?

It is contraindicated in children younger than 2 years. Further age-specific restrictions and precautions apply; consult the product leaflet and a qualified healthcare professional.

7. Can Phenergan replace epinephrine during anaphylaxis?

No. Epinephrine is the first-line emergency treatment for anaphylaxis. Phenergan must not delay or replace emergency treatment.

Medical Disclaimer

This content is for general product information and does not replace professional medical advice, diagnosis or treatment. Phenergan Injection must be administered by qualified healthcare professionals according to the exact product label. The risk of severe tissue injury and respiratory depression makes correct administration and patient monitoring essential.

Last Updated: October 25, 2026