Zelgor 250 mg Tablet

Zelgor 250 mg Tablet (Abiraterone)

Zelgor 250 mg Tablet contains abiraterone, a medication primarily used in the treatment of prostate cancer. Abiraterone works by inhibiting the enzyme CYP17, which is involved in testosterone production. By lowering testosterone levels, it helps to slow or stop the growth of prostate cancer cells that rely on this hormone.

Uses

• Treatment of Prostate Cancer: Specifically used for metastatic castration-resistant prostate cancer (mCRPC) and metastatic high-risk castration-sensitive prostate cancer (mCSPC), often in combination with other treatments such as prednisone.

How Zelgor Works

Abiraterone inhibits CYP17, an enzyme necessary for androgen production in the testes, adrenal glands, and prostate tumors. This leads to decreased levels of testosterone and other androgens, which are known to stimulate the growth of prostate cancer cells.

Common Side Effects

• Fatigue
• Hypertension (high blood pressure)
• Fluid retention (edema)
• Diarrhea
• Hypokalemia (low potassium levels)

Serious Side Effects (Seek Medical Attention)

• Liver toxicity (elevated liver enzymes)
• Cardiac problems such as heart failure or arrhythmias
• Severe adrenal insufficiency
• Severe hypertension

Key Features

• Contains abiraterone acetate, an androgen biosynthesis inhibitor.
• Lowers testosterone levels to inhibit prostate cancer progression.
• Often combined with corticosteroids to minimize side effects and improve efficacy.

Frequently Asked Questions (FAQ)

1. How should Zelgor 250 mg Tablet be taken?
   It should be taken on an empty stomach, at least 1 hour before or 2 hours after eating, as food can increase the absorption of abiraterone, potentially causing side effects.
2. Can Zelgor cause liver problems?
   Yes, liver function should be regularly monitored as abiraterone can elevate liver enzymes. Inform your healthcare provider of any signs of jaundice or abnormal liver function.
3. Is it safe to use Zelgor during pregnancy?
   No, Zelgor is not intended for use in women, and pregnant or breastfeeding women should avoid contact with the drug. Men taking Zelgor should use contraception to avoid potential harm to an unborn child.

References

1. Abiraterone Product Monograph – EMA
   Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/202379lbl.pdf
2. Prostate Cancer Treatment Guidelines – NCCN
   Available from: https://www.medicines.org.uk/emc/files/pil.2381.pdf