Nitisinone ( Generic Lasinone) is a competitive inhibitor of 4-hydroxyphenylpyruvate dioxygenase, an enzyme in the tyrosine catabolic pathway.
Mechanism: By preventing the normal catabolism of tyrosine, Nitisinone blocks the formation of toxic intermediates like maleylacetoacetate and fumarylacetoacetate.
Protection: These toxins are primarily responsible for liver failure, cirrhosis, and hepatocellular carcinoma in patients with HT-1.
Support: When used in conjunction with a tyrosine and phenylalanine-restricted diet, it allows for normal growth and liver function preservation.
Full Bioequivalence: Provides the same therapeutic outcomes as Orfadin, Nityr, and Haerliku.
Global Standards: Manufactured under strict pharmaceutical protocols to ensure purity and potency.
Proven Safety: Extensive clinical history in managing HT-1 symptoms and preventing neurological crises.
Cost-Effective Access: A sustainable alternative for long-term chronic management of metabolic disorders.
| Feature | Guideline |
| Dosing | Usually twice daily, adjusted by a specialist based on weight and blood tests. |
| Dietary Requirement | Must be combined with a specialized low-protein, tyrosine-restricted diet. |
| Monitoring | Regular plasma tyrosine and succinylacetone level checks are mandatory. |
| Eye Health | Periodic ophthalmic examinations are required due to potential tyrosine crystals. |
| Storage | Store between 2°C to 8°C (36°F to 46°F) or as specified by the manufacturer. |
Is Lasinone 10mg exactly the same as Orfadin or Nityr?
Yes. Lasinone contains the same active pharmaceutical ingredient (Nitisinone 10mg) and is clinically bioequivalent, meaning it performs the same function in the body as the originator brands.
Can Nitisinone cure Tyrosinemia Type 1?
Nitisinone is not a cure, but it is a life-saving management therapy. It stops the production of toxins that cause organ damage, allowing patients to lead healthy lives when combined with a proper diet.
Does Milan Medicals ship Nitisinone to the USA and UAE?
Yes. We provide secure, temperature-monitored (if required), and tracked international shipping to the USA, UAE, KSA, UK, and across Europe.
Are there specific side effects to monitor?
The most common side effects are related to high tyrosine levels, which can cause eye pain or sensitivity to light. Frequent blood monitoring helps prevent these issues.
Orders ship from our India Head Office within 1–2 business days of confirmation. We include full customs documentation — HS codes, certificates of origin, and pharmaceutical export permits.
Estimated delivery: 3–7 business days to UK. 7–10 business days to UAE, Saudi Arabia and Gulf countries. 10–15 days for USA and Asian countries.
All packages arrive in plain, unmarked brown boxes. No pharmacy name or medication details on the outside.
Nitisinone 10mg Capsule
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