Prasugrel 5mg Tablets — Generic Effient®/Efient® 5mg | Order Online

Prasugrel 5mg Tablets are a prescription antiplatelet medicine containing prasugrel 5mg as the active ingredient. They are the generic equivalent of Effient® 5mg (USA brand) and Efient® 5mg (UK/EU brand), the reference brand products. Prasugrel 5mg is the reduced maintenance dose of the thienopyridine P2Y12 inhibitor prasugrel, specifically indicated for patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) who are at higher bleeding risk due to low body weight (under 60kg) or advanced age (75 years or older). Generic prasugrel 5mg tablets are available internationally across the USA, UK, Australia, UAE, Germany, France, Russia, South Korea and worldwide.

Product Information

What Is Prasugrel 5mg Used For?

Prasugrel 5mg is indicated for the same core use as prasugrel 10mg — reducing the risk of thrombotic cardiovascular events in patients with ACS undergoing PCI — but specifically in patient subgroups at higher bleeding risk where the 10mg dose carries a less favourable risk-benefit profile.

United States: Effient® 5mg is indicated for patients with ACS managed with PCI who weigh less than 60kg. The prescribing information recommends considering the 5mg dose in these patients to reduce bleeding risk while maintaining antiplatelet benefit.

United Kingdom / EU: Efient® 5mg is indicated for ACS patients undergoing PCI who are aged 75 years or older, or who weigh less than 60kg. In patients aged 75 or older, prasugrel use is generally not recommended unless the patient is at high ischaemic risk and low bleeding risk — where prasugrel 5mg may be considered.

Australia: Prasugrel 5mg Australia — subject to TGA registration and ARTG listing. PBS subsidisation and specific eligibility criteria — confirm with your prescriber or pharmacist.

UAE / Gulf: Subject to UAE Ministry of Health registration. Consult a UAE-licensed physician for current prasugrel 5mg UAE availability.

Germany: Prasugrel 5mg Filmtabletten are available in Germany as Efient® 5mg and as generic prasugrel 5mg from multiple manufacturers. All are prescription-only (rezeptpflichtig).

France: Prasugrel 5mg comprimés pelliculés are available as Efient® 5mg and as generics in France, subject to HAS reimbursement.

Russia: Прасугрел 5 мг is available in Russia as Эффиент® 5 мг and as generic products, all requiring a valid prescription.

South Korea: 프라수그렐 5mg is registered per MFDS-approved labeling.

Always follow the prescribing information applicable to your country and the guidance of your licensed cardiologist or healthcare professional.

How Prasugrel 5mg Works

Prasugrel 5mg works through exactly the same mechanism as prasugrel 10mg — it is a thienopyridine prodrug that is converted in the body to an active thiol metabolite, which irreversibly blocks the P2Y12 ADP receptor on platelets. This inhibits ADP-mediated platelet activation and aggregation for the entire remaining lifetime of each affected platelet (7–10 days).

The 5mg maintenance dose delivers meaningful P2Y12 inhibition while reducing the degree of platelet inhibition compared to 10mg, resulting in a more favourable bleeding risk profile in vulnerable patient populations without eliminating antiplatelet benefit.

Why Prasugrel 5mg Instead of 10mg?

The choice between prasugrel 5mg and 10mg is based on individual patient risk assessment by the prescribing physician. The 5mg dose is specifically for:

Patients weighing less than 60kg
Lower body weight results in proportionally higher drug exposure at the 10mg dose, increasing bleeding risk without additional ischaemic benefit. The 5mg dose corrects this exposure imbalance.

Patients aged 75 years or older
Elderly patients have higher baseline bleeding risk. In the TRITON-TIMI 38 trial, patients aged 75 or older did not show a net clinical benefit from prasugrel 10mg compared to clopidogrel due to increased fatal and intracranial bleeding. Where prasugrel is clinically necessary in this age group, the 5mg dose is preferred.

Important: The loading dose remains 60mg regardless of whether the maintenance dose is 5mg or 10mg. Never adjust your dose without specific guidance from your cardiologist.

Prasugrel 5mg vs Prasugrel 10mg

Prasugrel 5mg vs Clopidogrel vs Ticagrelor

These medicines are not interchangeable. Dose and agent selection is made by your cardiologist based on your individual clinical profile.

Generic Prasugrel 5mg vs Effient®/Efient® 5mg

Effient® 5mg (USA) / Efient® 5mg (UK/EU) is the originator brand containing prasugrel 5mg. Generic prasugrel 5mg tablets contain the same active ingredient at the same strength but may differ in inactive ingredients, tablet appearance, packaging and manufacturer. Consult your pharmacist before switching between branded and generic prasugrel products.

Manufacturers of generic prasugrel 5mg available internationally include Accord, Teva, Sandoz, Aurobindo, Sun Pharma and others, depending on market.

Key Safety Information — Prasugrel 5mg

Bleeding Risk
Prasugrel 5mg still carries a significant bleeding risk, though lower than the 10mg dose. Platelet function is irreversibly inhibited and all bleeding events — including minor cuts, surgical procedures and gastrointestinal bleeding — may take longer to stop during treatment.

Absolute Contraindications

• Prior stroke or transient ischaemic attack (TIA) — black box warning in the USA; net harm demonstrated in clinical trials
• Active pathological bleeding
• Severe hepatic impairment
• Known hypersensitivity to prasugrel or any excipient

Do Not Stop Without Medical Guidance
Stopping prasugrel prematurely — particularly in patients with coronary stents — carries a serious risk of stent thrombosis, which can cause fatal myocardial infarction. Never discontinue prasugrel without first consulting your cardiologist.

Surgery
Prasugrel should be discontinued at least 7 days before elective surgery where bleeding control is required. Your surgical and cardiology teams must coordinate management.

Drug Interactions

• Warfarin and other anticoagulants — increased bleeding risk
• NSAIDs (chronic use) — increased bleeding risk
• SSRIs and SNRIs — increased bleeding risk
• Opioids — may delay absorption in STEMI patients

Always read the patient information leaflet and prescribing information applicable to your country.

Prasugrel 5mg — Availability by Country

Frequently Asked Questions — Prasugrel 5mg

What is Prasugrel 5mg used for?
Prasugrel 5mg is used in combination with aspirin to prevent blood clots in patients with acute coronary syndrome (ACS) undergoing PCI, specifically in those aged 75 or older or weighing less than 60kg — patient groups at higher bleeding risk on the standard 10mg dose.

Is Prasugrel 5mg the generic for Effient® 5mg / Efient® 5mg?
Yes. Effient® 5mg (USA) and Efient® 5mg (UK/EU) are the originator brands. Generic prasugrel 5mg tablets contain the same active ingredient and strength. Inactive ingredients, appearance and manufacturer may differ.

Why is Prasugrel 5mg used instead of 10mg?
Prasugrel 5mg is used in patients under 60kg or aged 75 or older, where the standard 10mg dose carries a higher bleeding risk without proportional additional ischaemic benefit. The 5mg dose maintains effective antiplatelet therapy with a more favourable safety profile in these patients.

What is the loading dose for Prasugrel 5mg?
The loading dose is 60mg regardless of maintenance dose — the same as for prasugrel 10mg. The maintenance dose of 5mg begins after the loading dose and is taken once daily with or without food.

Can Prasugrel 5mg be stopped before surgery?
Prasugrel must be discontinued at least 7 days before elective surgery. Never stop without consulting your cardiologist — premature discontinuation risks life-threatening stent thrombosis.

What is the difference between Prasugrel 5mg and Clopidogrel 75mg?
Both are thienopyridine P2Y12 inhibitors but prasugrel is more potent with faster, more consistent platelet inhibition. Prasugrel 5mg is contraindicated in prior stroke or TIA patients, where clopidogrel may remain an option. Dose and agent selection must be made by your cardiologist.

Is Prasugrel 5mg available in the UK?
Yes. Efient® 5mg and generic prasugrel 5mg tablets are available in the UK on prescription. Generic manufacturers include Accord, Teva and Sandoz among others.

Can I buy Prasugrel 5mg tablets online?
Prasugrel 5mg is prescription-only in the USA, UK, Australia, UAE and most markets worldwide. A valid prescription from a licensed prescriber is required.

Is Prasugrel 5mg available in Australia?
Prasugrel 5mg products are registered on the ARTG. PBS subsidisation depends on indication and patient eligibility. Confirm with your prescriber or pharmacist.

Medical Disclaimer

This information is provided for educational and commercial reference purposes only and is not a substitute for professional medical advice, diagnosis or treatment. Prasugrel 5mg is a prescription-only antiplatelet medicine with a significant bleeding risk and important contraindications including prior stroke or TIA. Always use it according to the applicable prescribing information and the advice of a qualified healthcare professional licensed in your country. Never stop taking prasugrel without first consulting your prescribing cardiologist.

Last Updated: September 25, 2026